11 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... differential #diagnosis #nephrology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... involvement: Anti-GBM ... #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Vasculitis: • Microscopic ... + 90% • Anti-GBM ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology ... #diseases
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
Differential Diagnosis Algorithm ... cells on urine microscopy ... disease • ... wall) • Anti-GBM ... • Pauci-immune disease
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Differential Diagnosis Algorithm ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... , ANA, Anti-GBM, ... Anti-ds-DNA, C3 ... Differential #Diagnosis #nephrology ... #causes
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... antibody, Anti-GBM ... usually low in anti-GBM ... Goodpasture's cause
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
): • Microscopic ... often causes arthritis ... glomerulonephritis) • Anti-GBM ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
)): Microscopic ... often causes arthritis ... GN Anti-GBM (10 ... disease, and ocular ... Differential #Diagnosis #Rheumatology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease)

What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology ... #pulmonary