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diagnosis algorithm management neurology vasculitis acute aki classification disorders glomerulonephritis hematology pulmonary renal workup ana anca antibodies antibody antineutrophil antinuclear
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... polyangiitis, Microscopic ... ab, anti-GBM ab ... biopsy By Tess Litchman ... #diagnosis #nephrology
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Glomerulonephritis - Differential ... Wegener's) • P-ANCA: Microscopic ... Churg Strauss) Anti-GBM ... #diagnosis #nephrology ... #causes
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
of cases) 2 ... Vasculitis: • Microscopic ... ANCA+ 90% • Anti-GBM ... antibodies #diagnosis #rheumatology ... #diseases
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM ... Disease (Goodpasture's
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... - Differential ... cells on urine microscopy ... disease • ... wall) • Anti-GBM
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... osmolarity If cause ... Vasculits: ANCA, ANA, Anti-GBM ... #Diagnosis #nephrology ... #causes
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... PT, aPTT(liver disease ... ), HBsAg/anti-HBc ... When do you do a BM ... #Workup #hematology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... Injury (AKI) - Differential ... Glomerulonephritis • Anti-GBM ... polyangiitis /microscopic ... #KidneyInjury #Nephrology
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