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diagnosis differential algorithm antibodies pulmonary renal vasculitis acute aki ana antibody antineutrophil antinuclear associations autoantibodies autoimmune classification comparison glomerular injury
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
' disease c-ANCA ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's ... #diagnosis #table ... #rheumatology #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
• Sjögren syndrome ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... antibodies #diagnosis #rheumatology ... #diseases
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... differential #diagnosis #nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology ... #comparison #table
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... , ANA, Anti-GBM, ... Anti-ds-DNA, C3 ... Differential #Diagnosis #nephrology ... #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic ... differential #diagnosis #rheumatology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... life-threatening diseases ... Auto-antibodies: ANCA ... antibody, Anti-GBM ... usually low in anti-GBM
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
)): Microscopic ... tract, and often causes ... abdominal pain and GN Anti-GBM ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... < 20 % IBM • Anti-cytoplasmic ... SYNDROME: • Fever ... statins - probably caused ... Myositis #Myopathy #rheumatology
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