8 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's ... diagnosis #table #rheumatology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
ANCA-positive vasculitis ... polyangiitis, Microscopic ... ab, anti-GBM ab ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANCA-Associated Vasculitis ... : • Microscopic ... Renal-limited vasculitis ... ANCA+ 90% • Anti-GBM ... antibodies #diagnosis #rheumatology
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA), microscopic ... involvement - PR3>MPO Microscopic ... 90%, rarely PR3 Anti-GBM ... disease - MPO>PR3 ... PR3 #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... (anti-C1q Vasculitis ... Dx: GPA, EGPA, microscopic ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
(PR3-ANCA)): Microscopic ... abdominal pain and GN Anti-GBM ... (anti-C1q Vasculitis ... (anti-C1q Vasculitis ... Differential #Diagnosis #Rheumatology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease)

What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... A small vessel vasculitis ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology