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diagnosis differential glomerulonephritis pulmonary causes diseases pathology acute aki anca antibodies antibody antigbm antineutrophil antinuclear blood classification clinical comparison electronmicroscopy
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... Basement Membrane ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
, renal, and post-renal ... interstitial disease ... GBM, Glomerular ... basement membrane ... Causes #Sites #Nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Basement Membrane ... membrane and alveolar ... basement membrane ... Diagnosis: • Anti-GBM ... #Membrane #Disease
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
of glomerular disease ... Basement Membrane ... staining on IF • No EM ... anti-proteinase ... Differential #Diagnosis #Nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Anti-Sm (Smith) ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... Jcortesizaguirr #ANA
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... nephropathy - Thin basement ... membrane disease ... of glomerular disease ... causes #urology #nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... membrane: Goodpasture ... life-threatening diseases ... antibody, Anti-GBM ... usually low in anti-GBM
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
acellular scanning EM ... second layer of basement ... membrane response ... ElectronMicroscopy #SEM ... #clinical #nephrology
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 Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
(Dense deposit disease ... immune deposits on EM ... microangiopathy (TMA), anti-phospholipid ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal
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