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diagnosis differential algorithm pulmonary rheumatology classification glomerular management neurology proteinuria renal syndrome vasculitis acute aki ana anca antibodies antibody antineutrophil
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... Microscopy (EM) ... Minimal change disease ... Amyloid RPGN • Anti-GBM ... #glomerular #diseases
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Disease (Goodpasture's ... Disease) What ... Diagnosis: • Anti-GBM ... #Membrane #Disease ... #Goodpastures #AntiGBM
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... Goodpasture's Disease ... dysmorphic RBCs) • Disease-specific ... ab, anti-GBM ab
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
Causes of acute ... and interstitial disease ... GBM, Glomerular ... basement membrane ... #Sites #Nephrology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
of glomerular disease ... Basement Membrane ... (GBM) • Typically ... Linear, ribbon-like GBM ... Differential #Diagnosis #Nephrology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... Vasculitis: • Microscopic ... ANCA+ 90% • Anti-GBM ... disease - MPO>PR3 ... #rheumatology #diseases
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
cells on urine microscopy ... nephropathy • Thin GBM ... disease • ... wall) • Anti-GBM ... • Pauci-immune disease
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology ... Diagnosis #Algorithm #Causes
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... life-threatening diseases ... Inflammatory eye disease ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Cytomegalovirus; GBM ... = glomerular basement ... impairment), heart disease ... diagnosis cluster, the diseases ... nephrotic #syndrome #nephrology
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