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diagnosis differential rheumatology antibodies causes renal table vasculitis algorithm ana anca anti antibody antigbm antineutrophil antinuclear associations autoantibodies basement classification
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Nephrotic syndrome ... RPGN • Anti-GBM ... #nephrology #pathology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... polyangiitis, Microscopic ... anti-ANCA ab, anti-GBM ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
(Diffuse) Anti-Sm ... La) - Sjogren's syndrome ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's ... syndrome #Autoantibodies
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), MPA (microscopic ... life-threatening diseases ... Inflammatory eye disease ... antibody, Anti-GBM ... usually low in anti-GBM
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-Sm (Smith) ... cases • Sjögren syndrome ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... disease - MPO>PR3
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Borrelia (Lyme Disease ... Viruses (HSV, EBV ... Miller-Fisher GBS ... - brain stem encephalitis ... Diagnosis #Causes #Neurology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
progressing GN • New pulmonary ... PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... • Cogan Syndrome ... Dx: GPA, EGPA, microscopic
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Mucocutaneous lymph node syndrome ... (PR3-ANCA)): Microscopic ... pain and GN Anti-GBM ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
(Goodpasture's Disease ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology ... #pulmonary
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