13 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Injury Hepatocellular ... Liver Injury ... • AST/ALT elevation ... • R value = (ALT ... Transaminitis #diagnosis #differential
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... ALP ≥ 2x ULN R Value ... ALP) ≥5: Hepatocellular ... injury >2 ... 2: Cholestatic injury
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... Acute Liver Injury ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... - +/- elevation ... Enzyme Elevation ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... Celiac Disease Hepatocellular ... #Injury #Differential ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury - Differential ... Injuryliver ... Liver Injury Differential ... #hepatology #algorithm
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Calculate R-Value ... • Hepatocellular ... #differential # ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... alternative causes • Hepatocellular ... dechallenge • Acute ... #Algorithm #hepatology
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
is made in the liver ... Hepatocellular injury ... Hepatocellular Injury ... Hematologic Malignancy ... extreme ferritin elevation
Causes of Sudden Unexpected Death in Infancy (SUDI) - Differential Diagnosis Algorithm
Congenital Anomaly / Disorder:
 •
Diagnosis Algorithm ... Neurologic Anomaly • Pulmonary ... Gastrointestinal infection Injury ... Accidental* Other: • Acute ... #Causes #Peds #