11 results
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
Differential Diagnosis Algorithm ... Definition: T.bili elevation ... Hyperbilirubinemia #direct #bilirubin ... #gastroenterology ... #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
LFTs) - Normal Values ... (GGT) - Liver, biliary ... Conjugated/DBili) - Biliary ... LFTs #Laboratory #Values ... Interpretation #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Drugs - Primary biliary ... PSC - Other biliary ... Differential #Diagnosis #Algorithm ... #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Function Test (LFTs) Elevation ... the liver ALP - Biliary ... ALP ≥ 2x ULN R Value ... FunctionTest #LFTs #Elevation ... Transaminitis #diagnosis #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Phosphatase and Bilirubin ... hepatocyte - Elevation ... initial insult Bilirubin ... ASTALT #AlkPhos #Bilirubin ... #Hepatology #Pathophysiology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... - +/- elevation ... of Liver Enzyme Elevation ... differential #diagnosis #algorithm ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Calculate R-Value ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... - +/- elevation ... week • Direct bilirubin ... : • Bilirubin: ... #differential #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... slightly elevated • Bilirubin ... No extrahepatic biliary ... diagnosis #workup #hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... anemia Indirect bilirubin ... Mild-to-moderate elevation ... Diagnosis #Workup #Hematology