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diagnosis algorithm gastroenterology lfts treatment abnormal aflp apml arterial bariatric biliary bypass chemistry cholangitis cirrhosis complications differentiation dili drug embolism
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... ongoing ↑ LFTs or symptoms ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... postpartum): • Initial symptoms ... infiltration) Differential ... #Pregnancy #hepatology ... #pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... priapism • Lab values ... : • Pathophysiology ... TLS #diagnosis #management ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH, Evans Syndrome ... Defects, Drugs, Liver ... #Diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... • Nephrotic Syndrome ... , Ischemic Liver ... Venous #Arterial #pathophysiology ... #hematology #differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Interpretation of LFTs R-value ... • Gilbert's syndrome ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... suspicious clinical symptoms ... presence of metabolic syndrome ... Abnormal #Algorithm #Hepatology ... #Differential #
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... PBC Signs and Symptoms ... or higher • Liver ... bile ducts Differential ... diagnosis #workup #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... Diagnosis and Management ... resolution of symptoms ... hepatopulmonary #syndrome ... #treatment #hepatology
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