26 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... • Conjugated Bilirubin ... #Metabolism #Pathophysiology ... #hepatology #Liver
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
LFTs) - Normal Values ... in bone Total bilirubin ... Indirect bilirubin ... LFTs #Laboratory #Values ... Interpretation #diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... Alcohol-Associated Hepatitis ... (DILI) Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... #gastroenterology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
ongoing ↑ LFTs or symptoms ... Calculate R-Value ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
>1.5, and both values ... - Serum total bilirubin ... ) or metabolic liver ... Possible drug-induced liver ... #Diagnosis #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
>1.5, and both values ... • Serum total bilirubin ... ) or metabolic liver ... Possible drug-induced liver ... #AH #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... Check Acute viral hepatitis ... Check Acute viral hepatitis ... week • Direct bilirubin ... #differential #Hepatology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
MRCP, ERCP, liver ... Hyperbilirubinemia #direct #bilirubin ... Diagnosis #Algorithm #gastroenterology ... #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... Phosphatase and Bilirubin ... initial insult Bilirubin ... ASTALT #AlkPhos #Bilirubin ... #Hepatology #Pathophysiology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
fold elevation, Bilirubin ... fold elevation, Bilirubin ... but variable ++, Bilirubin ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis