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Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... and Management ... Direct antiglobulin test ... #Management #Algorithm ... #hematology
Obstetric patients often pose challenges to anesthesiologists, as lab values and parameters vary from a non-pregnant
anesthesiologists, as lab values ... #diagnosis #clinical ... #management #anesthesia ... #anesthesiology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... Laboratory Tests ... #Differential #Diagnosis ... #hematology
Leptospirosis
Pathogen: Leptospira (interrogans, kirschneri, noguchii)
Risk Factors:
 • Occupational exposure - Farmers, ranchers, trappers, veterinarians
 • Recreational
failure • Severe pulmonary ... disease ARDS Diagnosis ... agglutination - test ... #microbiology #diagnosis ... #treatment #management
Our approach to the diagnosis and initial management of patients with suspected HIT. Our approach is
approach to the diagnosis ... and initial management ... HIT laboratory tests ... #Diagnosis #Management ... #Hematology #HIT
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... hepatitis • Pulmonary ... Stills #Disease #diagnosis ... #management #treatment ... #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Initial screening test ... #SLE #Summary #diagnosis ... #rheumatology # ... management
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... low, tests to detect ... indirect antiglobulin tests ... #Workup #Hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
and Management ... approach for post-test ... : Confirmatory test ... Management: • ... #Hematology #HemeOnc
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• HIV: 2/3 pulmonary ... Tuberculosis Diagnosis ... Tuberculin skin test ... Tuberculosis #TB #Diagnosis ... #Management #Treatment