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differential liver algorithm acute causes transaminitis classification dili elevation failure function gastroenterology hematology interpretation laboratory lactate management tests acidosis aclf
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Liver Function Tests ... Diagnosis Framework ... 1000): • DILI (Drug-induced ... liver injury) ... #Diagnosis #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
obstruction - Drug-Induced ... liver injury ... - Wilson disease ... #Differential #Hepatology ... #Diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
→ liver test abnormalities ... valproate, azoles), Drugs ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... symptoms of liver disease ... Calculate R-Value ... gastroenterology #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis ... #hepatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... >1.5, and both values ... suspect drug within ... atypical laboratory tests ... #Diagnosis #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... >1.5, and both values ... suspect drug within ... atypical laboratory tests ... #hepatology #criteria
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
- Differential Diagnosis ... • Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential Diagnosis ... , Recreational Drugs ... #Differential #Diagnosis ... Acute #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... Alcohol-related liver disease ... • Autoimmune hepatitis ... #Diagnosis #Algorithm ... #hepatology
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