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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... Calculate R-Value ... #DILI #Drug #induced ... gastroenterology #hepatology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
- Diagnosis and ... Management • ... • Shear stress-induced ... #Diagnosis #Management ... #treatment #hematology
Behcet's Syndrome - Diagnosis
Diagnostic Criteria for Behget's Syndrome (International Study Group for Behget's Disease):
 • Recurrent,
Behcet's Syndrome ... - Diagnosis Diagnostic ... Criteria for Behget's Syndrome ... Abnormal pathergy test ... #criteria #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
ulceration • Ocular ... Positive pathergy test ... is a skin prick test ... #diagnosis #management ... signs #symptoms #rheumatology
Our approach to the diagnosis and initial management of patients with suspected HIT. Our approach is
and initial management ... HIT laboratory tests ... #Diagnosis #Management ... #Hematology #HIT ... #Heparin #Induced
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... Drug-associated, PCH, Evans Syndrome ... Laboratory Tests ... #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Heparin Induced ... approach for post-test ... : Confirmatory test ... #HIT #Heparin #Induced ... #Hematology #HemeOnc
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Ocular- 50%: Ptosis ... Penicillamine induced ... Bedside: ice pack test ... /Edrophonium test ... #management #neurology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... >1.5, and both values ... Possible drug-induced ... atypical laboratory tests ... Hepatitis #AH #hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... Sepsis • Drug-induced ... Liver function tests ... #Diagnosis #Management ... #Hematology #Rheumatology