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management oncology hemeonc chronic differential hemophagocytic hlh leukemia lymphocytic lymphohistiocytosis syndrome workup algorithm apml bandemia cbc cell classification differentiation disorders
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... Lymphocytosis on CBC ... microglobulin Treatment ... Lymphocytic #Leukemia #diagnosis ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... minimal tumor burden Diagnosis ... Vmphocytosis on routine CBC ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Responsive to Treatment ... growth, response to treatment ... Classification #pathophysiology ... #Hematology #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... • Induce blast cell ... Renal Failure Treatment ... #management #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
Thrombocytopenia (HIT) - Diagnosis ... ♀, ↑Age, ESRD Pathophysiology ... Management: • D/c all ... #Management #Treatment ... #Hematology #HemeOnc
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Differential Diagnosis ... counts may delay diagnosis ... #differential #diagnosis ... neutrophil #WBC #CBC ... #hematology #pathophysiology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Splenomegaly Diagnosis ... : On the CBC, ... PV, MDS, CML) Treatment ... Thrombocythemia #ET #hematology ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
search for and treatment ... Pathophysiology ... of NK cells and CD8 ... Treatment Approach ... #Management #Hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Pathophysiology: ... Diagnosis (Clinical ... Treatment Overview ... evaluation essential in all ... Hepatorenal #Syndrome #Hepatology
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