19 results
diagnosis differential management hematology neurology nutrition pediatrics thrombocytosis acidosis aids aplastic b12 cancer cardiology celiac chf ckd classification cns cobalamin
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Inflammatory: • IBD ... disorders • Celiac disease ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... Loss (without anaemia ... (IBD, cancer) ... #Iron #Deficiency
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
• Iron-deficiency ... anemia unresponsive ... to treatment ... without discernable cause ... Inflammatory (IBD
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
fatigue despite clinical ... Crohn's > UC Anemia ... restricted diet/deficiency ... fatigue despite disease ... /other causes •
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... • GH Deficiency ... Panhypopituitarism Treatment ... Celiac, IBD) • ... endocrinology #causes
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... intrinsic factor, IF) Clinical ... diarrhea related to IBD ... , celiac disease ... Check for IF ab Treatment
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... Vasculitides, IBD ... , Celiac disease
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency ... Treatment:
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Infections+++: Virus ... Cellular immune deficiency ... Treatment: • ... inhibitors under evaluation
Occult and Lower Gastronintestinal Bleed - Differential Diagnosis Algorithm Occult (Stool + Occult blood and/or iron deficiency
Differential Diagnosis Algorithm ... blood and/or iron deficiency ... anemia) • Colorectal ... , asymptomatic IBD ... #Causes
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