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diagnosis management differential rheumatology dermatology fatigue gastroenterology hemophagocytic hepatology hlh lupus lymphohistiocytosis nephrology oncology sle summary table thrombocytosis aids antinxp2
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Inflammatory: • IBD ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Vasculitides, IBD ... , Celiac disease
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
- Diagnosis Algorithm ... Iron-deficiency anemia ... unresponsive to treatment ... without discernable cause ... Inflammatory (IBD
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
fatigue despite clinical ... , Anemia • Prevalence ... Crohn's > UC Anemia ... fatigue despite disease ... /other causes •
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... Epstein-Barr Virus ... Obstructive Pulmonary Disease
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Infections+++: Virus ... Drugs, Unknown cause ... Treatment: • ... inhibitors under evaluation
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... • Epstein-Barr virus ... Treatment: ... #oncology #hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... intrinsic factor, IF) Clinical ... diarrhea related to IBD ... , celiac disease ... Check for IF ab Treatment
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. Step 1: In the patient with
Algorithm regarding ... diagnosis and treatment ... normal, further evaluation ... of liver disease ... including liver and hematologic
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... Positive in 60-80% of cases ... life-threatening • Treatment ... management of SLE • Evolution ... : Chronic disease
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