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diagnosis differential hematology causes hemolysis management petechiae petechial aiha classification extravascular intravascular mcv purpuric skin thrombocytosis workup agglutinin allergy anemias
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Hemolytic Anemias ... Hemolytic Anemias ... Hypersplenism, Infection ... #hematology
Anemia - Hemolysis Diagnostic Algorithm Autoimmune hemolytic anemia Microangiopathic hemolytic anemia Probable thalassemia Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Autoimmune hemolytic ... hemolytic anemia ... #Anemia #Algorithm ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... idiopathic) - Autoimmune ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Differential Diagnosis Algorithm ... idiopathic, malignancy, autoimmune ... Fevers, DAT (-) → Infection ... #Diagnosis #Algorithm
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... , CKD • Hemolytic ... - Extrinsic: Autoimmune ... Macroangiopathic, Infections ... #MCV #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Cold AIHA • Alloimmune ... circulation - Infections ... anemia • ... #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... Polyclonal: - Infection ... #Hemolytic #Anemia ... Treatment #management #hematology
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Anemia (AIHA) ... - Secondary Infectious ... #Hemolytic #Anemia ... #Differential #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... inclusions - If infection ... elliptocytosis, autoimmune ... #workup #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... Antibody-mediated hemolysis ... deficiency Infections ... • Epstein-Barr virus
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