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diagnosis differential hematology algorithm management oncology sob aki apml bleeding bruising cardiology chronic cryofibrinogenemia differentiation emergencies encephalopathy endocarditis gap globulin
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Tamponade Pulmonary ... Causes of Dyspnea ... Hepatopulmonary syndrome ... Transverse myelitis • Hematology ... #pulmonary
Causes of Chronic Dyspnea - Differential Diagnosis Algorithm Pericardial • Effusion • Cardiac Tamponade* • Constriction Myocardial •
Causes of Chronic ... Dyspnea - Differential ... Stable Angina • Acute ... Coronary Syndrome ... Acidosis #Chronic #Dyspnea
Causes of Dyspnea - Differential Diagnosis Algorithm Cardiac: • Dysrhythmia • Ischemia • Cardiomyopathy • Valvular disease
Causes of Dyspnea ... Cardiomyopathy • Valvular ... Superior vena cava syndrome ... Emphysema • Cancer ... amzn.to/2LmUODZ #Dyspnea
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... - APLS • Acute ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis HEMODYNAMIC • Cardiac failure: Impaired forward flow,
Common causes of ... inhibitors, hepatorenal syndrome ... ) • Vascular occlusion ... fibrosis, cervical cancer ... NephroP #AKI #causes
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
of breath • Neurologic ... • Cough • Dyspnea ... Effusion: • Dyspnea ... Hyperuricemia • Acute ... differential #diagnosis #cancer
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Cathepsin G release → vascular ... Imaging: CXR- pulmonary ... Differentiation #Syndrome ... diagnosis #management #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... high WBC count cause ... Pulm: Hypoxia, dyspnea ... - ACS, AKI, acute ... diagnosis #management #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
may precede the neurologic ... Autoimmune disease, Cancer ... cortical lesions • Vascular ... , ADEM, Acute toxic ... the underlying cause
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... • Bone pain, dyspnea ... • Tumor lysis syndrome ... lymphoid organs When Cancer ... #Leukemia #Hematology
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