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diagnosis management differential druginduced erythematosus systemic classification hydroxychloroquine syndrome vasculitis adverseeffects approach arthritis behcets benefits cerebritis cns comparison cryoglobulinemia cryoglobulins
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... half-life = 40 days ([HCQI ... #rheumatology # ... pharmacology #levels ... #lupus #management
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... Associated - SLE ... • HCV, HBV Not ... Differential #Diagnosis #hematology ... #rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... life-threatening • Treatment ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... Puncture, EEG Treatment ... Erythematosus #SLE ... CNS #neurology #rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... Hydroxychloroquine #hcq ... Risks #Benefits #Lupus ... #pharmacology # ... #sideeffects #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... constitutional symptoms • Treatment ... Discontinuation of causal ... life-threatening • Treatment ... #table #rheumatology
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome - Treatment ... Ulcers: • Treatment ... immunosuppressive meds) Vascular ... #management #pharmacology ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Vascular Sludging ... (e.g. systemic lupus ... classification #rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Induced Systemic Lupus ... with drug-induced SLE ... for 1 year of treatment ... medications #drugs #pharmacology ... differential #diagnosis #rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
spondyloarthropathies, lupus ... Non-bloody: OA, avascular ... Like in this case ... Chronic = RA, SLE ... Joint #Pain #MSK #rheumatology
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