21 results
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Microcytic RBC: ... (sometimes) Macrocytic ... , McLeod blood group ... #microscopy #atlas
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Lead poisoning • Macrocytic ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... #differential #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Algorithm Normal Blood ... • Drugs Oval Macrocytes ... Myelodysplastic Syndromes ... Cells, Normal WBCs ... #Macrocytic
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
in peripheral blood ... High in acute blood ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic ... #Macrocytic
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
Pathologic Red Blood ... and Associated Diseases ... Morphologies #Key #Atlas #Microscopy ... #Pathology #Hematology ... Basis of Disease
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
chronic kidney disease ... , Acute blood loss ... MCV - >96fL - "Macrocytic ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Myeloproliferative Disease ... Workup: • Complete ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... , Drugs, Liver Disease ... Defects: Sickle cell anemia ... Electrolytes: Wilson's disease ... - Peripheral Blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... Abnormalities: macrocytic ... anemia, thrombocytopenia ... including peripheral blood ... Autoinflammatory #Somatic #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
for workup, including ... hematologic: Acute blood ... hemolysis, deficiency anemia ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome