15 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential ... management #treatment #rheumatology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Approach to Anemia - Differential ... Diagnosis Algorithm Blood ... Normochromic RBCs on Smear ... Spherocytes on Smear ... Algorithm #Causes #Hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Primary biliary cirrhosis ... (PBC) Anticentromere ... Microscopic polyangiitis ... U1-RNP antibody ... diagnosis #table #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Volume (MCV) - Differential ... Algorithm Normal Blood ... Smear • Drugs ... Cells, Normal WBCs ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... - Peripheral Blood ... Smear ↑ abnormal ... #Hemolysis #Differential ... #Diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... plateletcount), peripheral blood ... smear, HIV/HCV ... dysplasia on the smear ... Causes #Workup #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... disease, McLeod blood ... #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... cultures, including blood ... #Bandemia #differential ... #CBC #hematology ... #pathophysiology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
of Peripheral blood ... smear - Shows schistocytes ... from ischemia WBC ... count and differential ... Diagnosis #Workup #Hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... polarized light microscopy ... : • Complete blood ... count (CBC) • ... diagnosis #testing #Rheumatology