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Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
↑ LDH • Anti-RBC ... type ± C3d • Blood ... FOR a cause → Systematic ... diagnosis #management #treatment ... #rheumatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Iron deficiency anemia ... Chronic disease anemia ... disease, McLeod blood ... differential #diagnosis #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Diagnosis Algorithm Blood ... • Anemia of Chronic ... Non-lmmune #Anemia ... Algorithm #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Non malignant hematologic ... effect following treatment ... states • Non-hematologic ... Iron deficiency anemia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal Blood ... Neutrophils - Low RBC ... Cells, Normal WBCs ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... Iron-deficiency anemia ... coagulopathy (DIC) #RBC ... #differential #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... the peripheral blood ... including chronic blood ... > 3: • Acute blood ... Production #Index #hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... proportion of the red blood ... RBC are produced ... Pancytopenia is a hematologic ... three peripheral blood
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Diagnosis Algorithm - Systemic ... == Blood Glucose ... renal failure/uremia ... Hyperthyroidism CBC ... #generalized #dermatology
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency Anemia ... Tests: • MCV/RBC ... carrying component of blood ... Iron #Deficiency #Anemia ... Fe #diagnosis #hematology
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