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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis #causes
Interpretation of Components of the CBC (Complete Blood Count)

#CBC #Interpretation #CompleteBloodCount #Hematology #Differential #Diagnosis #Laboratory
Components of the CBC ... (Complete Blood ... Count) #CBC ... CompleteBloodCount #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Causes of Thrombocytosis ... Artifact (redo CBC ... effect following treatment ... Diagnosis #Algorithm #Causes ... #Hematology
Blood Product Components, Contents, Volume and Shelf Life

Whole blood (autologous or directed donations) - RBC and
Blood Product Components ... Life Whole blood ... Hct 35%. 450mL blood ... X 1010); some WBC ... Contents #Volume #Hematology
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Reactive: • Anemia/blood ... Non-infectious (malignancy, rheumatologic ... Differential #Diagnosis #causes ... #Platelets #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
↑ LDH • Anti-RBC ... type ± C3d • Blood ... 2) LOOK FOR a cause ... diagnosis #management #treatment ... #rheumatology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Features of hematologic ... platelets, persistent WBC ... Diagnosis #Algorithm #hematology ... #WBC #Leukemoid
ABO Blood Types and Transfusion Compatibility Table
A Blood Type:
 • RBC Antigens: A
 • Antibodies: Anti-B
ABO Blood Types ... Type: • RBC Antigens ... Type: • RBC Antigens ... Type: • RBC Antigens ... Compatibility #Table #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
decreased PLT count: CBC ... plateletcount), peripheral blood ... disease), HBsAg/anti-HBc ... or if a primary hematologic ... #Workup #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Algorithm Decreased WBCs ... Normal/lncreased WBCs ... Diagnosis #Algorithm #Causes ... #Hematology