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pocus diagnosis cardiology a4c hematology plax differential management algorithm effusion s4c smear pericardial microscopy pulmonary workup cardiac path bloodsmear causes
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Iron deficiency anemia ... disease, McLeod blood ... iron deficiency anemia ... Autoimmune hemolytic anemia
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... Hypertriglyceridemia • Uremia ... Glucose Content • RBC ... turnover • Acute blood ... • Hemolytic anemia
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... of peripheral blood ... Even with normal WBC ... cultures, including blood ... likelihood of negative clinical
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Diagnosis Algorithm Blood ... Deficiency • Aplastic Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... the peripheral blood ... including chronic blood ... > 3: • Acute blood ... , Intrinsic RBC
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... Iron-deficiency anemia ... Sideroblastic anemia ... coagulopathy (DIC) #RBC
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
proportion of the red blood ... RBC are produced ... destruction of RBC ... three peripheral blood ... well as varying clinical
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal Blood ... Neutrophils - Low RBC ... • Pernicious Anemia ... Cells, Normal WBCs
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... Autoimmune #Hemolytic #Anemia
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Megaloblastic Anemia ... #Peripheral #Blood ... interpretation #clinical ... #anemia
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