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rheumatology differential sle classification patterns anca antibody antineutrophil autoantibodies autoimmune cryoglobulinemia dermatology diseases laboratory management mimickers myopathy myositis oncology primary
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
lupus erythematosus ... Juvenile Idiopathic Arthritis ... lupus erythematosus ... lupus erythematosus ... #Antibodies #ANA
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
arthritis (RA) ... or systemic lupus ... SLE) Signs / Symptoms ... #Syndrome #Pathophysiology ... #Diagnosis #Signs
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Juvenile Idiopathic Arthritis ... scleroderma), Rheumatoid Arthritis ... , Sjögren Syndrome ... Juvenile Idiopathic Arthritis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... #erythematosus # ... signs #symptoms ... #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... arthritis) • ... lupus erythematosus ... SLE), rheumatoid arthritis ... , Sjögren's syndrome
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... erythematosus ... • Sjögren syndrome ... #antibodies #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, inflammatory arthritis ... arthritis, adult-onset ... Arthritis: • ... to: Arthritis, ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... : - Arthritis ... and Lupus Mimickers ... #Lupus #Erythematosus ... #signs #symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... Glomerulonephritis, arthritis ... mucositis - Rash, arthritis ... as systemic lupus ... Symptoms (Sx) in
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Syndrome Diagnosis ... ab • RF • Antinuclear ... Arthritis Malignancy ... #Syndrome #Rheumatology
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