10 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
arthritis (RA) ... or systemic lupus ... SLE) Signs / Symptoms ... #Syndrome #Pathophysiology ... #Diagnosis #Signs
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Juvenile Idiopathic Arthritis ... scleroderma), Rheumatoid Arthritis ... , Sjögren Syndrome ... Juvenile Idiopathic Arthritis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... • Sjögren syndrome ... #Antinuclear #Antibody ... #antibodies #diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
arthritis) • ... cytoplasmic antibody ... lupus erythematosus ... SLE), rheumatoid arthritis ... , Sjögren's syndrome
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... #erythematosus # ... signs #symptoms ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, inflammatory arthritis ... arthritis, adult-onset ... Arthritis: • ... to: Arthritis, ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often causes arthritis ... Glomerulonephritis, arthritis ... mucositis - Rash, arthritis ... as systemic lupus ... Symptoms (Sx) in
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
• Septic arthritis ... lupus erythematosus ... of Inflammatory Arthritis ... when rheumatoid arthritis ... of reactive arthritis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... GCA (Giant Cell Arteritis ... mucositis • Rash, arthritis ... often causes arthritis ... Glomerulonephritis, arthritis
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
of the joints (arthritis ... and Symptoms: ... of the joints (arthritis ... Neutrophilic rheumatoid arthritis ... #diagnosis #dermatology