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hematology causes workup hemolysis intravascular agglutinin anemias apml atlas classification cold differentiation disease hodgkins key lymphoma mcv monoclonal morphology normocytic
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Diagnosis Algorithm ... • Extrinsic RBC ... • Intrinsic RBC ... #Anemias #Differential ... #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... Diagnosis Algorithm ... elliptocytosis - RBC ... anemia • ... Differential #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... • Intrinsic RBC ... #Causes #differential ... #diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Diagnosis Algorithm ... Decreased WBCs ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... Diagnosis #Algorithm
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... to Anemia - Differential ... Diagnosis Framework ... Spherocytosis, G6PD, PK, HbC ... Diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... coagulopathy (DIC) #RBC ... Morphology #Atlas #key #diagnosis ... #differential # ... hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Diagnosis Algorithm ... hypertension • Unusual RBC ... #Anemia #Differential ... #Diagnosis #Algorithm
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Diagnosis Algorithm ... Initial Workup: CBC ... reticulocyte count, LFTs ... ↑ Destruction (hemolysis ... #Diagnosis #Algorithm
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... anemia Indirect ... from ischemia WBC ... count and differential ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Blood smear - RBC ... younger pts) Differential ... the RBCs causing intravascular ... #anemia #hematology
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