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hematology differential mds apml atlas cancer causes classification differentiation disorders key leukemia lymphocytic markers morphology myelodysplasia platelets rbc syndromes thrombocytosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... transformation to acute ... #Diagnosis #Management ... #treatment #hematology ... #oncology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm ... Blood Loss ... • Acute Bleed - ... Deficiency • Aplastic ... #Hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Algorithm Acute ... - CD7, CD3 Chronic ... • Lymphoid (CLL ... bcr-able (+) ↑ WBC ... #Disorders #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... • Aplastic Anemia ... Marrow Failure • Chronic ... #Syndromes #diagnosis ... #hematology #oncology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Liver diseases, Myelodysplastic ... Malignant tumors, Acute ... PD deficiency, Pulmonary ... #differential #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... → Refer to hematology ... blood loss, Acute ... • Infections: Chronic ... #Algorithm #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... aplasia • ITP ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... Imaging: CXR- pulmonary ... #management #hematology ... #oncology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
treatment algorithm ... clonal evolution to acute ... median age at diagnosis ... approaches. ... #algorithm #hematology
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