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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology #
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Features of hematologic ... platelets, persistent WBC ... Diagnosis #Algorithm #hematology ... #WBC #Leukemoid
Interpretation of Components of the CBC (Complete Blood Count)

#CBC #Interpretation #CompleteBloodCount #Hematology #Differential #Diagnosis #Laboratory
Components of the CBC ... Blood Count) #CBC ... CompleteBloodCount #Hematology
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilic Syndrome ... Hypereosinophilic Syndrome ... suspect underlying hematologic ... Hypereosinophilic #Syndrome ... #HES #Hematology
Dysplasia in Myelodysplastic Syndrome 
 - 
Dysgranulopoiesis 
 - Dyserythropoiesis 
 - Dysmegakaryopoiesis 

#Dysplasias #MDS #Myelodysplastic
Myelodysplastic Syndrome ... Myelodysplastic #Syndrome ... #Pathology #Hematology
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia

Fanconi Anemia
Acquired Aplastic Anemia
Dyskeratosis Congenita & Telemore Biology
Marrow Failure Syndromes ... Shwachman-Diamond Syndrome ... #Pancytopenia #Syndromes ... anemia #diagnosis #Hematology
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
- Defects in RBC ... - Defects in RBC ... Hemolytic #Anemia #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Artifact (redo CBC ... Non malignant hematologic ... states • Non-hematologic ... Algorithm #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Algorithm Decreased WBCs ... Normal/lncreased WBCs ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... Algorithm #Causes #Hematology