14 results
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology ... Microangiopathic Hemolytic ... Cold autoimmune hemolytic ... #RBC #Morphology ... diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... #differential # ... diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... and RES-mediated hemolysis ... elliptocytosis - RBC ... Intravascular - Hemolysis ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Anemia #Differential ... #workup #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... coagulopathy (DIC) #RBC ... hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... 3) Internal (RBC ... Urobilinogen #Hemolysis ... Diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... Blood smear - RBC ... Diagnosis Monoclonal ... #hemolytic #anemia ... #hematology #diagnosis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
transform into a RBC ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Production #Index #hematology ... #diagnosis #calculation
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
hemorrhage and hemolysis ... intravascular hemolysis ... out an immune hemolytic ... from ischemia WBC ... #Workup #Hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
+Organomegaly+↑RBC ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology