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Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... Even with normal WBC ... 21% had normal WBC ... #Bandemia #differential ... #pathophysiology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... if high risk if WBC ... initiation • Differential ... QD until normal WBC
Urine Microscopy and Casts - Image Atlas Key - Squamous Epithelial Casts - Transitional Epithelial Cells - Renal Tubular
Hyaline Cast - WBCs ... Granular Casts - WBC ... Cast - RBC Cast
Algorithm and Differential Diagnosis of Macroscopic Hematuria Important Historical Elements: - Painless: suggests malignancy - Painful: suggests calculi/infection - Urinalysis:
Algorithm and Differential ... dysmorphic RBC’s, RBC ... /WBC casts, proteinuria ... #Macroscopic #Differential
Urinalysis Interpretation (UA) Bacteria, Leukocyte esterase, WBC, Nitrite, RBC, Epithelial cells, pH #Diagnosis #Urinalysis #Interpretation #Analysis
Leukocyte esterase, WBC ... , Nitrite, RBC,
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 Pathophysiology of Hemolytic Anemia - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects) -
Pathophysiology ... - Defects in RBC ... - Defects in RBC ... environment #Pathophysiology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Lymphadenopathy - Differential ... (Pancytopenia, WBC ... differential includes ... Lymphocytic Leukemia (CBC ... Lymphadenopathy #LAD #Differential
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... platelets, persistent WBC ... #Leukocytosis #Differential ... Algorithm #hematology #WBC
Hyperkalemia Differential Diagnosis Algorithm R/O Pseudo-hyperkalemia: • Possible Lab error! Alwavs Repeat Blood sample! • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential ... ischemia-induced RBC ... hemolysis) • RBC ... #Hyperkalemia #Differential ... potassium #high #pathophysiology
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
WBC and platelets ... Hct of 70-80% - RBC ... X 1010); some WBC ... plasma, a few RBC ... X 1011); some WBC
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