694 results
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Algorithm Decreased WBCs ... Normal/lncreased WBCs ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC
Urine Microscopy and Casts - Image Atlas Key

- Squamous Epithelial Casts
- Transitional Epithelial Cells
- Renal Tubular
Hyaline Cast - WBCs ... - Monomorphic RBCs ... - Dysmorphic RBCs ... Granular Casts - WBC ... Cast - RBC Cast
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Decreased RBC ... Infiltration Increased RBC ... Thalassemia • RBC ... Disorder • RBC
Urinalysis Interpretation (UA)

Bacteria, Leukocyte esterase, WBC, Nitrite, RBC, Epithelial 
cells, pH

#Diagnosis #Urinalysis #Interpretation #Analysis
Leukocyte esterase, WBC ... , Nitrite, RBC,
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Morphology Microcytic RBC ... sometimes) Macrocytic RBC ... Bite Cell RBC: G6PD ... Red #BloodCell #RBC
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... • Extrinsic RBC ... • Intrinsic RBC ... #Hemolytic #Anemias
Blood Product Components, Contents, Volume and Shelf Life

Whole blood (autologous or directed donations) - RBC and
directed donations) - RBC ... WBC and platelets ... Hct of 70-80% - RBC ... X 1010); some WBC ... X 1011); some WBC
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
== Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... • Hemolytic anemia ... Dilutional Effect • RBC
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Pathophysiology of Hemolytic Anemia ... - Defects in RBC ... - Defects in RBC ... Pathophysiology #Hemolytic #Anemia