138 results
Bone Tumor Location within the Skeleton

Epiphysis: 
Only a few lesions are located in the epiphysis, so
Metaphysis: NOF, SBC ... Ewing's sarcoma, SBC ... , ABC, Enchondroma ... Epiphysis #Radiology #MSK ... #Differential #
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Even with normal WBC ... relative to both WBC ... bacteremia • Abnormal WBC ... 21% had normal WBC ... diagnosis #neutrophil #WBC
Peritonitis - Spontaneous vs Secondary vs Peritoneal Dialysis Associated Peritonitis
Spontaneous Bacterial Peritonitis
 • Cirrhosis (high SAAG)
PMN > 250 • Treatment ... at least 2): 1) Clinical ... cloudy effluent) 2) WBC ... > 100 WBC, >50% ... Peritoneal #diagnosis #differential
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
↑ LDH • Anti-RBC ... • Blood smear: Differential ... Anemia #diagnosis #management ... #treatment #rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... • Lab values: WBC ... organ damage • Treatment ... Low calcium • Treatment ... TLS #diagnosis #management
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
WBC <2k: Noninflammatory ... lower limbs) • WBC ... spondyloarthropathies • WBC ... presentation with lower WBC ... #Joint #Pain #MSK
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Artifact (redo CBC ... effect following treatment ... Thrombocytosis #Differential
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... if high risk if WBC ... initiation • Differential ... QD until normal WBC ... APML #diagnosis #management
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Microangiopathy (TMA) - Differential ... Diagnosis and Management ... Initial labs: CBC ... Microangiopathy #TMA #Differential ... #Diagnosis #Management
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS) Mayo Clinic ... CBC, complete blood ... algorithm #diagnosis #management