29 results
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... • Drugs Oval Macrocytes ... Cells, Normal WBCs ... #Macrocytic ... #Hematology
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypoproliferative Macrocytic ... Anemia812 ... Hypothyroid • Liver Disease ... diagnosis #algorithm #hematology ... #workup
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
) Morphology Microcytic ... anemia (sometimes ... (sometimes) Macrocytic ... RBC: Vitamin B12 ... differential #diagnosis #hematology
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
95 (or 100) is macrocytic ... (EPO), iron or B12 ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic ... #Macrocytic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Spherocytosis, G6PD, PK, HbC ... Infections Macrocytic ... Folate deficiency, B12 ... Non-megaloblastic: Liver disease ... Differential #Diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
chronic kidney disease ... MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin B12 ... differential #diagnosis #causes ... #hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
evaluation of macrocytic ... (RBC = red blood ... the most likely cause ... recovery also causes ... of the initial work-up
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Deficiency • B12 ... Disease • Marrow ... #Classification ... Diagnosis #Algorithm #Causes ... #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
: macrocytic > normocytic ... ↑ LDH • Anti-RBC ... 2) LOOK FOR a cause ... diagnosis #management #treatment ... #rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... (>100 fL) • B12 ... #MCV #Classification ... Diagnosis #Algorithm #Causes ... #Hematology