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diagnosis hematology oncology algorithm management aafp agglutinin antibody atlas autoimmune bloodcell bloodsmear classification cll cold disease folate folicacid hodgkins homocysteine
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
AIHA • Anemia ... : macrocytic > normocytic ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Microcytic RBC: ... (sometimes) Macrocytic ... disease, McLeod blood ... #Morphology #differential
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... (RBC = red blood ... ordering a peripheral smear ... Hemorrhage or hemolysis ... of the initial work-up
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
Wright-stained peripheral blood ... smears the small ... can be found in hemolytic ... #Clinical #Path ... #BloodSmear #Blood
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Peripheral Smear ... hematology for workup ... hematologic: Acute blood ... loss, Acute hemolysis ... , deficiency anemia
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
of Peripheral blood ... smear - Shows schistocytes ... from ischemia WBC ... count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... Immunoglobulin M (IgM) • Blood ... smear - RBC agglutination ... younger pts) Differential ... sensitize red blood
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Peripheral Smear ... common cytopenia: Macrocytic ... Marrow Failure • Chronic ... differential •
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Peripheral smear ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... nodosum • Immune hemolytic ... Hodgkin Lymphoma Workup ... platelets - WBC ... Immunohistochemical studies (to differentiate
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