11 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... Hemolytic Anemia ... type ± C3d • Blood ... smear: Differential ... #Autoimmune #Hemolytic
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... DIC, TTP, HUS) ... Microspherocytes: Autoimmune ... hemolytic anemia ... interpretation #clinical
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... • Peripheral blood ... smear + DAT + further ... , DIC, eclampsia ... #Anemia #Differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... MAHA: TTP, HUS, DIC ... Membrane): - Autoimmune ... - Peripheral Blood ... Smear ↑ abnormal
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... thrombocytopenia - DIC ... elliptocytosis, autoimmune ... #Anemia #Differential ... Diagnosis #Algorithm #workup
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... Viral Infection Clinical ... smear - RBC agglutination ... younger pts) Differential ... sensitize red blood
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
of Peripheral blood ... smear - Shows schistocytes ... from ischemia WBC ... count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... of peripheral blood ... Corticosteroid use • Autoimmune ... #differential # ... #pathophysiology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
Pathophysiology ... Lung Abscess - Clinical ... Diagnosis: • CBC ... Leukocytosis, anemia ... • Sputum/Blood
Babesiosis on Peripheral Smear
85 M from SE USA, hx splenectomy, IgG4 plasmacytic syndrome: F, chills, profound
post exchange: blood ... inclusions, improved clinically ... lysis: fever, anemia ... complications: ARDS and DIC ... cryopreservation but in abscess