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diagnosis differential management signs hematology lupus erythematosus causes algorithm neurology treatment arthritis classification oncology thrombocytopenia vasculitis ana antinuclear autoantibodies autoimmune
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Demyelinating syndromes ... pain (20%) Renal disease ... ) Blood (75%): Anemia ... #signs #symptoms ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Initial screening test ... block • Sjogren syndrome ... polymyositis overlap syndrome ... #Summary #diagnosis ... #rheumatology #
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... and Symptoms: ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... #workup
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Abnormality • SLE ... Iron deficiency anemia ... halt nail growth (e.g ... • Nephrotic syndrome ... #Differential #Diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Hemolytic anemia ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... erythematosus (SLE ... ) Signs / Symptoms ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(eg, systemic juvenile ... erythematosus [SLE ... with leukopenia, anemia ... Liver function tests ... #Diagnosis #Management
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... ), Sjogren's Syndrome ... : Lupus (SLE), Systemic ... ANA #patterns #rheumatology ... #diagnosis #differential
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... Oral aphthae : SLE ... • Arthritis: SLE ... #signs #symptoms ... #rheumatology #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Workup History ... (GI symptoms/endemic ... , ANA (e.g., SLE ... changes), high MCV anemia ... #hematology
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