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diagnosis differential algorithm management lad leukemia lymphadenopathy diffuse focal hodgkins lymphocytic lymphoma mds myelodysplastic workup allergy basophilia basophils classification common
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... and Localized Lymphadenopathy ... Diffuse #Focal #Localized ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... (Chronic Myeloid ... -> AML: Blast crises ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... • Cancer #Localized ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... incompetent • CLL ... #Chronic #Lymphocytic ... diagnosis #workup #oncology ... #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Age > 50 • Chronic ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... hemorrhage) • Chronic ... Myelofibrosis (MF) • Chronic ... myeloid leukemia (CML ... #hematology #secondary
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
typically of B-cell ... Adenopathy (painless)-localized ... Lymphomas • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Causes of false- ... amyloidosis Other causes ... diseases, CML, ... MGUS #diagnosis #hematology ... #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... Allogeneic stem cell ... Management #treatment #hematology ... #oncology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
total white blood cell ... Disorders: • Chronic ... Chickenpox Other Causes ... Differential #Diagnosis #causes ... #hematology #basophils
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