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diagnosis hematology management algorithm differential causes liver medications thrombocytosis aclf aih akd aki autoimmune cirrhosis ckd cll definitions dili diuresis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... or Chronic Inflammatory ... disorders • Celiac disease ... effect following treatment ... Algorithm #Causes #Hematology
Definitions of AKI, CKD, AKD Acute Kidney Injury (AKI): • Increase in SCr by 2 50% within
AKI, CKD, AKD Acute ... • Oliguria Chronic ... Kidney Disease ... per 1.73 m2 • Stable ... #Definitions #nephrology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... • Infections: Chronic
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Torsemide) • Acute ... hyperaldosteronism • Acute ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology ... #Medications #Table
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... - Acute Bleeding ... Chronic Management ... #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... Alcohol-related liver disease ... dechallenge • Acute ... or chronic atypical ... Diagnosis #Algorithm #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
from subclinical disease ... to acute liver ... - Symptoms of chronic ... regarding need for treatment ... Diagnosis #Management #Hepatology
Causes of Myoclonus - Differential Diagnosis LOCALIZATION: • Cortical: Focal/multifocal: Distal UL+ Face, Action/sensitive induced • Sub-Cortical:
stroke, trauma • Acute ... encephalopathies, CJD • Chronic ... : Storage disease ... degenerations, dementias ... malabsorbtion (celiac, whipple
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... cells can indicate disease ... microglobulin Treatment ... ’s lymphoma or acute ... leukemia #CLL #Chronic
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