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differential anca dermatology mpo pain algorithm associated canca causes classification conditions dermatologic extrarticular glomerulonephritis granulomatosis hemoptysis panca polyangiitis polychondritis positivity
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
With associated pulmonary ... Negative IF): • PR3 ... ANCA (C-ANCA): GPA ... >>> MPA > eGPA ... , MPA >>> GPA Stanford
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated Vasculitis ... polyangiitis (GPA ... polyangiitis (MPA ... polyangiitis (EGPA ... #Diagnosis #Rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
(AAV): GPA (granulomatous ... polyangiitis), EGPA ... DAH), asthma in EGPA ... subglottic stenosis) in GPA ... #management #treatment
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
ANCA-Associated Vasculitis ... • GPA - PR3-ANCA ... ANCA negative • EGPA ... Renal-limited vasculitis ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
capillaritis • EGPA ... 60% • GPA: ... and branches • GCA ... • ANCA (Dx: GPA ... , EGPA, microscopic
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... polyangiitis (GPA ... GPA causes disease ... polyangiitis • EGPA ... #Polyangiitis #GPA
Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy
- Differential Diagnosis ... Kaposi's sarcoma • Rheumatologic ... Autoimmune: ANCA-Assoc vasculitis ... (GPA > EGPA, MPA ... #pulmonary #causes
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
, Sarcoidosis, GPA ... polychondritis, GPA ... cell arteritis, GPA ... Reactive arthritis, GPA ... severe sinusitis - GPA
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Elevated ESR and CRP GCA ... develop in pts with GCA ... progressive) EGPA ... 60/ GPA (Granulomatosis ... #Rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... Sarcoidosis • GPA ... #dermatology #joint ... #differential #diagnosis ... #rheumatology
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