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Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
- Differential Diagnosis ... Myelodysplasia Nutritional ... deficiency: • ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... Diseases: • GATA2 deficiency ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis Nutritional ... #Hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
clotting factor deficiency ... Patient has a factor deficiency ... Mixing #Study #diagnosis ... #hematology #pathophysiology ... #hematology #laboratory
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
Diagnosing Vitamin ... inadequate to diagnosis ... the first line tests ... #Diagnosis #Nutrition ... #Hematology #ComparisonTable
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Acute hemolysis, deficiency ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
• Vitamin K deficiency ... • Factor VII deficiency ... • Underfilled test ... Thromboplastin #laboratory #hematology ... #diagnosis
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency ... Anemia (IDA) Tests ... total body iron stores ... #ferritin #Fe #diagnosis ... #hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Purpura (TTP) Diagnosis ... severe, ADAMTS13 deficiency ... PLEX and RTX • Short-term ... management #treatment #rheumatology ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... • Folate Deficiency ... Non-lmmune: • HELLP Syndrome ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... mobilize folate stores ... depleted tissue stores ... #differential #diagnosis ... #hematology #nutrition
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