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diagnosis neurology hematology signs differential erythematosus hemophagocytic hlh lupus lymphohistiocytosis pseudogout sle systemic treatment vasculitis als amyotrophic apml barre behcet
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
joints (shoulders, wrists ... • Underlying disease ... states Pathophysiology ... • Metabolic syndrome ... Gout #Comparison #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
(CPPD) Pathophysiology ... joints (shoulders, wrists ... Crowned Dens Syndrome ... #Rheumatology # ... diagnosis #management
Chondrocalcinosis: Calcium Pyrophosphate Dihydrate (CPPD) Deposition Disease - Acute CPPD precipitation into the joint space ->
) Deposition Disease ... - Acute CPPD ... affected — e.g., wrist ... #Disease #Signs ... #Symptoms #Pathophysiology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Polyneuropathy, Cranial nerve ... Demyelinating syndromes ... pain (20%) Renal disease ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... : • Pathophysiology ... TLS #diagnosis #management ... #hematology
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Pathogenesis and Joint diseases ... small joints (wrists ... Stimulation of nerve ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... meningitis), MCC CNS symptoms ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... , PRES Pathophysiology ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
and peripheral nerves ... • Cogan Syndrome ... Presentation - Systemic Symptoms ... Nerves -> mononeuritis ... differential #diagnosis #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... APML #diagnosis #management ... #hematology #oncology
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