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differential management signs hematology erythematosus sle comparison classification oncology syndrome antinuclear arthritis msk neurology pathophysiology treatment vasculitis antibodies autoantibodies dermatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... lupus erythematosus ... connective tissue disease ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... lupus erythematosus ... : Lupus (SLE), Systemic ... #patterns #rheumatology ... #diagnosis #differential
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... distal to elbows/wrists ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... #workup
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SSc: systemic sclerosis ... lupus. ... LungDisease #CTILD #Diagnosis ... Differential #Comparison #Table ... #Pulmonary #Rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... Hydroxychloroquine *Short ... #SLE #Summary #diagnosis ... #rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... : - ANA > ... Evolution: Chronic disease ... #Summary #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Auto-Antibodies: - ANA ... and Lupus Mimickers ... #signs #symptoms ... #differential #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
months to years) Systemic ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology # ... diagnosis #management
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
M DAMN SHARP - Lupus ... Antinuclear Antibody (ANA ... Arthritis R Renal Disease ... IMDAMNSHARP #sle #systemic ... #rheumatology #
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... pain (20%) Renal disease ... Thrombocytopenia #Lupus ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
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