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diagnosis management differential clinical hematology erythematosus lupus signs sle video causes disease oncology symptoms cppd monoclonal ophthalmology treatment workup abnormal
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... joints Nervous system ... Demyelinating syndromes ... ) Blood (75%): Anemia ... symptoms #diagnosis #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Autoimmune Diseases: • Systemic ... Differential #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... hypersensitivity syndromes ... with leukopenia, anemia ... #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
clubbing Clarkson/Systemic ... et diutinum Neurologic ... neuropathy) • Systemic ... (-) hemolytic anemia ... Paraproteinemias #Hematology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
Diagnostic Criteria - Systemic ... SEROSITIS - RENAL - NEUROLOGIC ... - HEMOLYTIC ANEMIA ... absence of hemolytic anemia ... #Diagnosis #Rheumatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Differential Diagnosis Neurologic-Centered ... : (+) Systemic ... capillary leak syndrome ... • Schnitzler syndrome ... Differential #Diagnosis #hematology
Pisa Syndrome (pleurothotonus) on Physical Exam A tonic flexion of the trunk of the body to one
Pisa Syndrome (pleurothotonus ... Parkinson, Multiple System ... Pathophysiology: ... pleurothotonus #PhysicalExam ... #clinical #neurology
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 Upper Extremity Dermatomes and Myotomes Motor Function Shoulder: • Abduction - C5,C6 (axillary) • Adduction - C6, C7,
Pronation - C7, C8 Wrist ... Wrist drop - Occurs ... Carpal Tunnel Syndrome ... Myotomes #diagnosis #neurology ... sensory #motor #arm #physicalexam
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
Stevens-Johnson Syndrome ... , asthenia • Neurologic ... , headache • Systemic ... #SideEffects #Pathophysiology
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