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diagnosis differential hematology hypertension pathophysiology workup acute aflp algorithm antiphospholipid apl apml arterial auer comparison embolism endocarditis fatty generalized hus
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperviscosity, TTP, APLS ... Intravenous Drug Use • Pregnancy ... from prosthetic valves ... Infected cardiac valves ... coagulation and other causes
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Fatty Liver of Pregnancy ... : • Defect in fetal ... = nonspecific (nausea ... #Fatty #Liver #Pregnancy ... #hepatology #obstetrics
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
features in most cases ... promyelocytic #leukemia #APL ... APML #Pathology #Hematology ... #Clinical #Smear
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Resp/Heme: CHF, valves ... Rhabdomyolysis, Critical ... Polyneuropathy, ALS ... Differential #Diagnosis #causes
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... (catastrophic APS ... transplant, infection, pregnancy ... Microangiopathy #TMAs #hematology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
>10 mmHg - clinically ... Post-Hepatic: • Cardiac causes ... Fatty liver of pregnancy ... Differential #Diagnosis #causes ... #hepatology
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Causes of Secondary ... previously stable values ... 109 mm Hg) with clinical ... Pregnancy-associated ... Hypertension #Workup #causes
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
high index of clinical ... Autoimmune (SLE/APLS ... Hypercoagulable states • Clinical ... left-sided heart valves ... in up to 30% of cases
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid Syndrome (APLS ... - 1 or more clinical ... • Unexplained pregnancy ... maternal chromosomal causes ... ARUPConsult @ARUPLabs #APLS
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