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diagnosis management differential hematology workup classification lupus neurology thrombocytopenia treatment acidosis admissions admitting algorithm arthritis barre cerebritis checklist cns conditions
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... Autoimmune • ITP • SLE ... Foreign Surface (e.g ... #Hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... intake) • Target blood ... Insufficient blood ... (e.g. renal failure ... #rheumatology #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
plateletcount), peripheral blood ... smear, HIV/HCV ... function test, ANA (e.g ... ., SLE), anti-phospholipid ... #Workup #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... thrombosis and/or blood-brain ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
disease, Vasculitis (e.g ... arteritis • Bloody ... Heberden's nodes (DIP ... Bouchard's nodes (PIP ... differential #diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Phagocytosis of blood ... Autoimmune diseases: SLE ... of emergency, ICU ... treatment #summary #rheumatology
Admitting in the ICU - Checklist VITALS: If bad, stop and go see the patient immediately; you
Admitting in the ICU ... bad, stop and go see ... will also get an EKG ... Troponin, TSH, CPK, HIV ... diagnosis #workup #criticalcare
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Polyarthritis: • Blood ... : • Complete blood ... inflammatory disease (e.g ... Chemistry profile (e.g
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... HBV infection, HIV ... tissue disorder (e.g ... classification #rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
removal from the blood ... by excretion (e.g ... its metabolism (e.g ... again we might see ... Ethylene glycol - HIV
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