23 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... INR), Prolonged PTT ... Differential #Diagnosis #Algorithm ... #Causes #Hematology ... #coagulation #disorders
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Nonspecific inhibitors e.g ... to one factor e.g ... e.g. heparin ... inhibitory drugs e.g ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology ... #coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Rare • Drugs (e.g ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Differential Diagnosis Algorithm ... • Thrombus (e.g ... Myeloproliferative disorders (eg ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Toxic Damage (e.g ... Displacement (e.g ... Foreign Surface (e.g ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
: INR/PT, aPTT(liver ... function test, ANA (e.g ... (CVID, WAS), (neurologic ... or if a primary hematologic ... #Workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... (usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... differential #diagnosis #hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm
Infection
 • Bacterial
 • Abscess
 • Viral
Medications
Causes of Neutrophilia ... Differential Diagnosis Algorithm ... Solid Tumour (e.g ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
• Provoked (e.g ... screening, CBC, aPTT ... Hypercoagulable #Workup #hematology ... #diagnosis #algorithm ... #hematology #VTE