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diagnosis differential management rheumatology symptoms treatment algorithm secondary syndromes workup anemia anesthesia anesthesiology antibodies arteritis associations autoantibodies barre bee cardiology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... Foreign Surface (e.g ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... - Vasculitis, e.g ... - Vasculitis, e.g ... diseases #diagnosis #table ... #rheumatology #
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia Focal Hyporeflexia: • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
polyneuropathy (e.g ... Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome ... differential #diagnosis #table ... #neurology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... inflammatory disorders (e.g ... . autoimmune, TB ... Myelodysplastic syndrome ... #hematology #secondary
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
(e.g. oculomotor ... AQP4-lgG disease; e.g ... Myositis, Comorbid autoimmune ... Manifestations #diagnosis #neurology ... #symptoms #signs
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Infected thrombosis, (e.g ... Lemierre's syndrome ... Malignancy: - Hematologic ... Inflammatory Diseases (e.g ... . autoimmune): Lupus
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... Hepatitis • HIV Autoimmune ... Pulmonary Disease Neurologic ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Sclerosis (MS) is an autoimmune-mediated ... • Or brainstem syndromes ... Radiographic findings (eg ... Laboratory findings (eg ... VEP’s: EEG of visual
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Surgical devices, e.g ... Sepsis (→ 3-14) e.g ... (e.g. haloperidol ... hyperthermia crisis (late sign ... Phaeochromocytoma Neurologic
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