518 results
Atypical HUS - Hemolytic Uremic Syndrome
Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
shigatoxin mediated, aHUS ... still present with anemia ... rule out TTP. aHUS ... If this is aHUS, ... #aHUS #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... DIC, TTP, HELLP, HUS ... , aHUS, mechanical ... ARUPLabs #Hemolytic #Anemia
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
microangiopathic hemolytic anemia ... overlap TTP or aHUS
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Autoimmune Hemolytic Anemias ... (AHAs) Nonimmune-mediated ... #Hemolytic #Anemias
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Toxin-Mediated HUS ... (ST-HUS) • Atypical ... HUS (aHUS) ... differential #diagnosis #HUS
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Megaloblastic Anemia ... Microangiopathic hemolytic anemia ... DIC, TTP, HUS) ... Autoimmune hemolytic anemia ... interpretation #clinical #anemia
Differential Diagnosis of Anemias #Diagnosis #IM #Honc #Anemia #Differential #Iron #Algorithm #Microcytic #Macrocytic #Normocytic #Ddxof
Differential Diagnosis of Anemias ... Diagnosis #IM #Honc #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... → Sickle Cell anemia ... Microangiopathic hemolytic anemia ... (TTP, HUS, DIC, ... UnremarkableLab #Hemolytic #Anemia
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
hemolytic-uremic syndrome (ST-HUS ... known as atypical HUS ... macroangiopathic hemolytic anemia
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
for Hemolytic Anemia ... • MAHA: TTP, HUS ... #Hemolytic #Anemia